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PDF Exposure.
Paricalcitol partly preserved the ultrafiltration capacity upon PDF exposure.
Liver imprints were taken after seven weeks of PDF exposure.
Glucose absorption increased, although not significantly, from 33.3% to 42.8% upon PDF exposure.
However, upon PDF exposure, loss of ultrafiltration capacity ensued which was fully rescued by paricalcitol treatment.
In addition, paricalcitol treatment mitigated IL12p70 concentrations, whose production is related to M1 macrophages [ 24], upon PDF exposure.
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Here, we show indeed that the PDF exposure-induced increase in VEGF, after seven weeks of treatment, is attenuated by paricalcitol treatment.
The PDF exposure-promoted MMT (cells coexpressing cytokeratin and FSP-1 with double positive staining, yellow) is reduced by Rapamycin administration.
However, although there were significant differences between the intervention and control conditions in the time they spent on the DA respectively on the PDF, actual exposure to the DA might have been too low.
The "distance" between the pdfs of soft data and the BME estimates was assessed in terms of the relative entropy measure: where p k and q k represent the pdfs of the exposure observations and the BME estimates, respectively.
Exposure to PDF changed D/P creatinine from 0.2 to 0.4 (p < 0.01 versus group I).
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