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We evaluated pCR rate of cisplatin with pemetrexed in non small-cell lunon small-cell
Comparisons between experimental endpoints and the pCR rate and metastasis-free and overall survival were made.
Overall pCR rate was 39% (39% with TAX vs. 40% with non-TAX, p = 0.9).
Changes in the magnetic resonance metabolite ratios and pO(2) were related to the pCR rate.
For patients who had surgery, the pCR rate was also the same (28%) in both arms.
The pCR rate for all assessable patients was 26% in each arm.
These relationships may have interfered with our ability to obtain the pCR rate predicted by thermal doses achieved in these patients.
The pretreatment phosphomonoester (PME /Pi ratio also correlated inversely with the pCR rate (odds ratio of percentage of necrosis > or =95% = 0.06 for pretreatment PME/Pi ratio >0.8 vs. < or =0.8, Wald p = 0.023).
The pCR rate was 8%.
The overall pCR rate was 64%.
However the pCR rate was low.
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