Exact(3)
MYO6 was involved in cancer cell dissemination and described as a potential PCa marker [ 22, 23].
So far, most of PCa marker studies mainly focus on single genes, while how the discovered genes interact together to exert a significant combined effect on PCa still remains elusive.
Thus, it is of great significance to search for a more sensitive and more specific PCa marker that can provide valuable information for the diagnosis and treatment of the disease.
Similar(57)
A survey in the GEO indicated that NGS is currently finding modest application in the identification of PCa markers.
Another study utilising qPCR to study common PCa markers found a reduction of PSCA RNA expression in malignant compared with benign tissue (Fuessel et al, 2003).
Typically arranged in a monomorphic pattern, NEPC cells stain positive for neuroendocrine markers such as chromogranin A (CHGA) and synaptophysin (SYP) but negative for PCa markers like androgen receptor (AR) and prostate-specific antigen (PSA) [ 4].
A further difference to the report from Sheehan et al (2007) is that our immunohistochemical analysis of claudin-4 was supported by a comparative evaluation of AMACR and PSMA, two well-established PCa markers.
The arrays were made up of a panel of putative PCa markers primarily derived from an analysis of published microarray data using artificial neuronal networks (ANNs) (Narayanan and Keedwell, 2006).
Research into a panel of eight putative diagnostic markers identified one gene as a significant predictor of PCa (Rizzi et al, 2008), whereas another study began with a panel of nine PCa markers and identified one as diagnostic, but a further three that were indicative of organ-confined disease (Schmidt et al, 2006).
The amount of urinary exosomes decreases after androgen deprivation therapy, and some PCa markers (specifically, PSA, PSMA, and tumor-associated marker T54) have sometimes been detected in urinary exosomes but never in healthy donor samples; in one patient, the decrease of exosomal PSA was clearly related to treatment [ 101].
Pubmed was used to search for PCa prognosis markers and progression markers.
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