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Dots of different colors represented different PC count tertiles.
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EAAT2 levels and PC counts.
EAAT2 levels and PC counts of 16 ET cases and 13 controls were shown.
PC counts were averaged between raters for three separate animals per genotype per age.
EAAT2 protein levels were positively correlated with PC counts (Pearson's correlation coefficient r = 0.53, p = 0.004, i.e., individuals with lower EAAT2 levels had lower PC counts) (Additional file 4: Figure S3).
Further quantitative analysis of mean Purkinje cell (PC) counts revealed that mutant rats had significantly greater PC loss than normal rats regardless of treatment (F = 6.63; P < 0.01).
PC counts (CD19+C20−CD27high) decreased significantly upon proteasome inhibition from a median 7.07/µL at baseline to 1.65/��L 10 days after the last bortezomib cycle (54.4% reduction, p=0.015, figure 3A).
In this specific subset of patients, the difference in abnormal PC counts was statistically significant between the seven-colour strategy (median 8.3 × 10−5, range 2.6 14.7) and the six-colour strategy (median 3.7 × 10−5, range 0 3.7, P=0.0002); P=0.0002.
ω-Agatoxin at 150 nM did not affect the CB+- and L7/Pcp-2+-PC cornt or Cav2.1 protein expression in rIgG and untreated naive controls.
ANA, anti-nuclear antibodies; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; Hb, haemoglobin; ns, not statistically significant at P ≥0.05; PC, platelet count;; RF, rheumatoid factor; *VAS, visual analogue scale; WCC, white cell count.
PC: Peptide count.
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