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Mice were injected intradermally or intra-articularly in the knee joint space with recombinant murine CXCL1 (KC) (PeproTech, London, UK) 3 μg/site in phosphate-buffered saline (PBS) [ 45]. PBS administration was used as a control.
Vehicle (PBS) administration was used as a negative control.
The mean histological score was significantly lower than after PBS administration (P = 0.041).
Blood, lungs and spleens were harvested at 6 hours after LPS or PBS administration.
As Figure 6B demonstrates, the administration of the anti-NRP1B antibody significantly reduced the severity of paw inflammation indicated by the change in clinical score compared to PBS administration (P < 0.001).
Also, in Lewis rats given adoptive transfer of MBP T-cells, treatment with the iron chelator dexrazoxane (25 mg/kg given on days 1, 3 and 5 after the transfer of cells) led to reduced clinical signs and fewer T-cells and macrophages entering the spinal cord compared to PBS administration (Weilbach et al., 2004; Table 1).
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The results indicate that decreased food motivation may be a factor that contributes to the behavioral effects of PB administration.
These changes often tended to reverse those of similar size that had occurred during Pb administration.
Concurrent PB administration to LEV can increase the clearance of LEV significantly in dogs [ 36].
These effects occur in the initial weeks of treatment and may be magnified by concurrent PB administration.
Recently, it has been demonstrated that PB administration significantly alters the pharmacokinetics of levetiracetam in normal dogs [ 73].
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