Sentence examples for pbpk it from inspiring English sources

Although this approach may be mathematically similar to a PBPK, it is completely different philosophically.

Hence, to derive the most value from PBPK it is critical to ask the right questions, be clear on any assumptions, and to design appropriate experiments with appropriate statistical rigor that have the best chance of providing data and information to enable discriminating between possible models.

The major design philosophy behind PKQuest is to increase the predictive power of the PBPK so that it can applied to a large variety of solutes without the need for this specific information.

A physiologically based pharmacokinetic (PBPK) model would make it possible to simulate the dynamics of chemical absorption, distribution, metabolism, and elimination (ADME) from different routes of exposures and, in theory, could be used to evaluate associations between exposures and biomarker measurements in blood or urine.

Section 2 covers applications within the pharmaceutical industry, the integration of PBPK with pharmacodynamics, as well as PBPK modeling of populations; it finishes with a short chapter on the use of PBPK in drug discovery and development.

The first component of this approach is to integrate it in a PBPK framework.

This is the feature that has limited the applications of PBPK to human studies since it is normally assumed that these tissue partition coefficients must be determined for each specific solute that is studied.

Once a reference PBPK model has been established, it can be used to extrapolate between species or individuals outside the selected cohort and allows a straightforward extension to additional mechanistic details such as target-side pharmacokinetic/pharmacodynamic (PK/PD) interaction.

The author rightly stresses that nonetheless it is important that those applying the methodology should understand the concepts and methodologies underpinning PBPK, as well as its current limitations.

The established PBPK model was verified before applying it to the evaluation of DDI resulting from blinatumomab-mediated cytokine elevations.

For the prediction of human brain ECF exposure on the basis of human CSF concentrations, the PBPK modeling approach is important, as it allowed the extrapolation of our rat data.