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The mice with grafts grown from their own cells showed a significant improvement in their ability to control paw movements on the afflicted side.
A positive response was considered if the animal withdrew its hind paw within 6 to 8 seconds except any hind paw movements due to locomotion.
Hind paw movements directed away from the injection site (e.g. ear-scratching), licking or biting of the toes and grooming movements were not counted.
Cases when the paw slid across the pasta piece with no digit movement or repositioning were not counted, nor were paw movements that did not contact the pasta.
They displayed poor nest building and increased footslips per distance traveled in parallel rod footslip, indicating deficits in purposeful paw movements and motor dysfunction.
Thus, as a result of the de-synchronization of front and hind paw movements, the diagonal limbs no longer moved in phase with each other, as illustrated in the Hildebrand plots in Figure 4C.
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In about 25% of the attempts, the animals could move the robotic arm simply by firing the neurons that normally control their paw movement, Chapin says.
The normal responses to formalin-induced nociception also indicate that neuronal circuits for acute pain sensation and muscle reflexes for paw movement are not affected by the loss of the HDAC4 catalytic domain.
Purposeful paw movement is also normal, as assayed by nest building after 24 hr (G ).
The large, sinusoidal amplitude of the tail oscillations and their time-delayed relationship to hind paw movement suggested to us that tail movements in pcd could reflect passive consequences of the forward movement of the hind limbs.
Most of the measures relate to paw movement, whereas traditionally issues of coordination (e.g. in studies examining the role of the cerebellum, as cited in the paper) consider interactions between joints.
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