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CIA mice exhibited increased paw areas, increased stride frequency, shorter stride length, relative paw placement inversion, and reduced stride, stance, braking, swing, and propulsion durations.
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Gait parameters in the sham-operated animals did not change over time with the exception of the maximum paw area at peak stance, this being due to the marked increase in foot size and weight of the animals over time.
Longitudinal analysis, however, showed early decreases in paw area.
Postural and kinematic gait measurements are also calculated, including stride time, stride length, and paw area.
However, maximal paw area was reduced in LAMP-2-deficient mice.
Using DigiGait, we are able to quantify the maximal paw area in contact with the treadmill during the stance phase of the step cycle and demonstrate that the paw area increased with increasing clinical scores.
We found that paw area was the best predictor of the severity of spontaneous OA in STR/Ort mice.
Contusions were made in the "hind paw" area, which consists of overlapping motor and somatosensory fields [ 16].
We discovered links between specific gait modifications and OA severity, with paw area identified as being potentially predictive.
The signal intensity depended on the paw area in contact with the platform and increased with the pressure applied by the paw.
It is evident that decreased paw area suggests greater weight focus to a smaller foot area, consistent with the protection of specific joint locations from weight bearing.
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