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This could have a fine-tuning regulatory role, by modulating the speed of elongation and/or by providing pausing times at specific sites to allow for interaction with additional regulatory molecules.
We calculate empirical estimates of pausing times based on a simple model of translation where pausing times at a codon depend only on its cognate tRNA abundances and associated wobble parameters (Ikemura 1981; Andersson and Kurland 1990; Sørensen and Pedersen 1991; Kanaya et al. 1999; Gilchrist and Wagner 2006; Zaher and Green 2009; Shah et al. 2013).
Specifically, codons with higher abundances of cognate and near-cognate tRNAs are thought to have both shorter pausing times and lower error rates than codons with lower abundances of cognate and near-cognate tRNA (Ikemura [1981]; Kurland [1992], though see Shah and Gilchrist [2010] for a more nuanced view).
These differences, in turn, are predicted to lead to differences in ribosome pausing times and error rates between codons.
Although the contributions of these factors to ribosomal pausing times are often idiosyncratic and vary widely between genes, they can all influence the cost benefit ratio η.
The assumption that natural selection favors codon usage which reduces the protein synthesis cost benefit ratio η implies that the strength of this selection should scale with the gene's protein synthesis rate: Highly expressed genes should show the strongest bias for codons with shorter pausing times and error rates (Ikemura 1981 , 1985 Sharp and Li 1986 , 1987.
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Mobile sinks could attain a maximum speed up to 14 m/s with 5 s pause time.
Lightning can also pause time using an ability called Chronostasis.
No group difference was found for intersegmental pausing time or any interaction effect with the type of task.
Main Outcome Measures: Mean velocity, coefficients of variation of both length and movement time per segment, and mean intersegmental pausing time were calculated for each sequence.
(C ) The histogram shows the time between the start of gliding motility and the pausing time of the last retrograde IFT train in the leading flagellum.
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