A crucial limitation of the PWM approach is the paucity of a sufficient number of high confidence, experimentally verified binding sites.
These factors, together with the relative paucity of U2A′, are sufficient to maintain U1A localization to the U1 snRNP and restrict U2B″/U2A′ binding.
13 One relevant systematic review described new roles in emergency medical services (EMS) with some cost-saving, 14 but a paucity of studies with sufficient patient follow-up and consideration of training costs means that cost analyses are unreliable.
However, genome-wide significance of these findings has not yet been achieved, partly because of the paucity of available datasets of sufficient sample size (and hence power) for replication studies.
The evidence base for the treatment of delirium is less strong; however it is possible that this represents a lack of formal evidence as a consequence of a paucity of studies of a sufficient size [ 10].
Thus, the absence of active STAT5 in Wip1 KO hormone-sensing cells and the subsequent paucity of RANKL may be sufficient to explain a delay in tumorigenesis.
2 Despite the shortcomings of the legislation identified above (i.e., paucity of prosecution of cases and lack of sufficient protection to potential victims), it must be noted that the 1999 law and human right norms present many advantages.
Hence, an important finding of our systematic review is that there is a paucity of available data with a sufficient level of detail to ascertain the effects of STI co-infection on the risk of HIV sexual transmission risk for individuals on ART.
Although we acknowledge that our approach has weaknesses concerning the definition of positive controls, it provides nevertheless a new opportunity for breaking a vicious circle between lack of sufficient reference compounds and a paucity of validated assays.
The availability of sufficient samples with appropriate mutations has been recognized as a critical issue in genetic testing, given the paucity of validated clinical inherited disease gene samples [ 43].
