How individual ORC subunits co-assemble with each other and the nature of the structural transitions that occur within ORC and other pre-RC components during nucleotide-dependent initiation steps are ill-defined, in part due to a paucity of structures for key ORC reaction states.
Although the transmembrane (TM) region of a helical-bundle protein can be predicted reliably using first principles or machine-learning methods (Bernsel et al., 2008; Jones 2007; Lo et al., 2008), the mechanisms by which TM proteins fold into native structures remain poorly understood due to the paucity of solved structures.
The paucity of Man8GlcNAc2 structures in the Ngly1p-dependent fOS pool is intriguing as some ERAD pathways are thought to involve mannose trimming of the N-glycans of misfolded glycoproteins [50].
One striking characteristic of our proposed ERRE structure is the relative paucity of stable stem structures and abundance of single-stranded loops, several of which are unusually large.
Given the paucity of inhibitor-bound structures of p300 and other HATs, we determined the structure of p300 bound to the nonhydrolyzable acetyl-CoA analogue, acetonyl-CoA, which contains an extra methylene unit between CoA and the acetyl moiety.
In his book "Asian Eclipse", Michael Backman argues that the damage wrought on each Asian country was in direct proportion to the amount of cronyism and corruption, the paucity of the legal structures and corporate accountability, and the general lack of ethics prevailing there.
Before modification, this cell line showed a paucity of cell adhesion structures by ultrastructural and immunohistochemical analysis, whereas immunoblot studies demonstrated that expression and association of E-cadherin and catenins were not diminished when compared with normal keratinocytes.
Due to the paucity of double-labeled structures, no quantitative evaluation was performed.
One of the major problems in understanding the mechanisms of action of this family of channels is the paucity of high-resolution structures.
The term 'empty nose syndrome' was initially used to describe certain symptoms associated with tissue loss and radiographic findings of a paucity of normal anatomic structures within the nasal cavities.
