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Interestingly, the paucity of patients with KGDH deficiency further support the relevance of this specific enzymatic function63.
Namely, the dose of heparin and percent of patients on glycoprotein IIb/IIIa inhibitors were unnecessarily high, and a paucity of patients were on bivalirudin, which decreases bleeding and improves outcomes compared with heparin and glycoprotein IIb/IIIa inhibitors.
A limitation of this study was the relatively small size of the patient groups, a limitation based on the paucity of patients within a given study group from whom there were cryopreserved cells.
There was also a paucity of patients with solid tumors (n = 2).
Genotype phenotype correlations are still only speculative, due in large part to the paucity of patients with any particular mutation.
Likewise, the paucity of patients using intestinal-acting glucocorticoids did not allow for exploring subcategories according to the timing of use.
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The lack of patient derived DSRCT cell lines and paucity of patient derived tumor samples reflect the rarity of the tumor.
Specifically for ABCC6, the paucity of patient tissue due to difficulties with prelevation (e.g., for the liver or eye) also presents an important hurdle.
The relative paucity of patient data related to this topic makes it difficult to investigate switching rates in the human host.
Besides kidney cells, the expression profile of ABCC6 also led to the use of HEPG2 cells as an in vitro model system to study polarized human hepatocytes, particularly because of the paucity of patient-derived tissue from this organ.
No improvements in DIPG outcome have been noted in the past 20 years, perhaps due to the paucity of patient-derived samples and lack of molecular insights leading to novel treatments.
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