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Oxidative stress is particularly harmful in neurons, because these cells almost entirely rely on OxPhos for energy production, due to a paucity of key enzymes in the glycolytic pathway, including PFKFB3, which is highly degraded at the UPS due to high activity of the E3 ubiquitin ligase, anaphase-promoting complex/cyclosome (APC/C -Cdh1, in neurons12,13.
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How individual ORC subunits co-assemble with each other and the nature of the structural transitions that occur within ORC and other pre-RC components during nucleotide-dependent initiation steps are ill-defined, in part due to a paucity of structures for key ORC reaction states.
There is a paucity of information regarding various key aspects of system design encountered in this new area of research.
There is a paucity of information on the key drivers, including soil and coastal erosion, flooding, air and water pollution, gas flaring, and climate change.
Thus whilst concerns regarding rates of self-harm among asylum seekers have been frequently raised, a paucity of systematic information regarding key factors associated with self-harm among asylum seekers exists.
Researchers have long been frustrated by a paucity of fossils from this key period in evolution, which sits at the borderline between two major geological epochs: the Miocene (about 23 million to 5 million years ago) and the Oligocene (about 34 million to 23 million years ago).
Shearman felt that the episode's minimalism its paucity of dialogue and music was key to its tone, and praised Henriksen's expressiveness for helping to shape this.
Lack of vaccination is due partly to uncertainty of the disease burden arising from a paucity of epidemiological information in key locations.
Although this is a very crude metric, it shows both the paucity of research in this key area and increasing interest in it.
It's cheering to see the issue of women in radio raised and it's about time, given the discrepancy between a potential audience that's 52% female and the indefensible paucity of women's voices in some key sectors of radio.
In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com