The paucity of coding variants in this relatively large gene was surprising as we did not identify any amino acid substitutions other than the known p.Leu107Val (rs695871) polymorphism.
A physiological role for FMO5 is also suspected, due to the small number of xenobiotic substrates for the enzyme and the paucity of coding-region SNPs in the FMO5 gene.
However, in contrast with this paucity of protein coding 'genes', there is an enormous complexity in transcription and the protein coding mRNAs contribute to a very small fraction of transcripts in comparison with the different varieties of non-coding RNAs (ncRNAs).
Given the paucity of brain expressed coding-genes with high rates of evolution identified in the majority of genome scans (e.g. [ 49- 52] but see [ 53]) this raises the intriguing possibility that microcephaly genes are hotspots for positive selection among brain expressed coding genes.
We also focus on smoking and obesity, due to their impact on health trajectories, rapid shifts in prevalence, substantial geographic variation in rates 18 and paucity of international evidence on completeness of coding.
Compared to the nuclear genome, mitochondrial DNA (mtDNA) has a modified genetic code, a paucity of introns, and the absence of histone protection.
This conclusion is supported further by the highly biased distribution of sequences detected in exosomes over only a subset of genes in the leishmania genome combined with a striking paucity of transcripts derived from protein coding genes which are otherwise abundant in total cellular RNA.
Most bacterial symbionts share many genomic features including small genomes, nucleotide composition bias, high coding density, and a paucity of mobile DNA, consistent with long-term host association.
Thus, ascertainment biases could explain the paucity of reliable examples of TE-derived protein coding sequences uncovered via the analysis of experimentally characterized protein sequence data sets [ 13, 16].
DHPLC analysis the FANCD2 gene indicated a high level of conservation in the coding sequence, indicated by a paucity of missense changes.
Other drawbacks include the lack of a single industry standard for 2-D bar codes in the United States, and the relative paucity of phones that can use 2-D.
