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The paucity of changes in high abundance species observed in CLL patient samples may have a number of explanations.
Overall, the results of our dataset were not useful for evaluating the relative effectiveness of the various methods due to the paucity of changes in some lineages.
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16p11.2 copy number changes generally occur de novo, during meiosis (Sebat et al., 2007), and the paucity of inherited changes indicates its importance for normal health and reproduction (Levy et al., 2011; Weiss et al., 2008).
This lack of enthusiasm may be due to the paucity of tissue changes even in severe clinical presentations [ 56], the sometimes overwhelming severity of non-specific ictal and postictal changes, and the elusive ambition to localise an epileptic focus in the huge brain without EEG and functional imaging data or a thorough sampling scheme.
DHPLC analysis the FANCD2 gene indicated a high level of conservation in the coding sequence, indicated by a paucity of missense changes.
However, we did not see the predicted paucity of TAA nonsilent changes among SCLs compared with TGA and TAG changes (Fisher's exact test, P > 0.05).
Despite a paucity of large expression changes, we found a strong correlation between the variance of gene expression change and species divergence (R2 = 0.90).
There is a paucity of studies examining changes in brain activation patterns across the menstrual cycle and a need for randomized studies of hormone therapy in postmenopausal women to confirm findings from observational studies.
There is also a paucity of reports investigating changes in these parameters as pregnancy progresses.
However, in the current study we showed that the failure could occur due to a paucity of observed molecular changes.
To date there has been a paucity of evidence regarding changes in the B-cell repertoire with age.
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CEO of Professional Science Editing for Scientists @ prosciediting.com