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In order to further evaluate whether inbreeding per se influences patterns, we included two studies on the effect of inbreeding on the transcriptome [13], [14].
To obtain information on fine-scale long-term spatial patterns, we included one-dimensional penalized splines for a priori selected GIS-derived time-invariant covariates.
To assess whether exposures or predictors influenced weight patterns, we included interactions between age and each covariate and age-squared and each covariate.
To aid in the analysis of expression patterns, we included the electronic northern expression module to detect the gene expression differences in each library through comparison with accession numbers from BLAST functional annotation.
To control for intrasummer seasonal patterns, we included in the all models natural cubic spline (NCS) functions with 3 degrees of freedom (df) for summer date (i.e., from day 1 to day 91 of the summer season).
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To investigate this seasonal pattern we included city–season specific temperature in the meta-regression analysis.
Of note, among the miRNAs selected to study the expression pattern, we included miR-252 and miR-276, which were represented by both the -3p and -5p strands.
Another characteristic is that the Esb layers simulated with MIRE model reveal a typical downward movement pattern when we included the electric fields in our simulations also.
However, to avoid confusion for those readers from the wider fields of pattern recognition, we included the following explicit definition of our terminology in the revised manuscript: "Similarly, masked multi-reference refinement may be used as a clustering tool, i.e. to separate experimental particle images based on differences in a defined region of interest.
To illustrate themes and patterns, we have included examples and quotes for specific cases.
In order to get a better idea of the clinical outcomes underlying the observed prescription patterns, we have included a more detailed description of the most incident types of drugs at the 3-digit and 4-digit ATC level (see online supplementary table S1).
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CEO of Professional Science Editing for Scientists @ prosciediting.com