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In the scenarios of high disease risk in the present model, including case importation stabilizes patterns of vaccine
However, each of these scenarios simulated different patterns of vaccine distribution across age groups.
We did not observe systematic patterns of vaccine acceptance or refusal based on adolescent age or years of clinician experience.
From in-depth discussions with school nurses, nurses identified four patterns of vaccine decision-making behaviours (we have termed these: active acceptors, passive acceptors, passive rejectors and active rejectors).
Similar(55)
A mathematical model of HPV type 16 infection and progression to cervical cancer, parameterised to represent the infection in Finland, was used to explore the optimal age at vaccination and pattern of vaccine introduction.
The spatial pattern of vaccine delivery around barriers is contingent upon the availability of funds (D Slate, pers comm).
The model can accommodate any pattern of vaccine waning and inclusion of booster shots.
As expected, the method of loading the tumor antigens onto the dendritic cells, either pulsing with defined peptides (protocol 3, n = 24) or electroporation with mRNA encoding the tumor antigens (protocol 2, n = 17), did not affect the concentration or the pattern of vaccine-induced anti-KLH humoral responses (Fig. 3c).
This study also underscores the need for more detailed data collected at local levels (eg, ZIP code), as patterns of HPV vaccine receipt were found to differ significantly from aggregated state and national patterns.
Strikingly, not much attention has been paid to the dynamics, levels and patterns of the vaccine-induced anti-KLH humoral responses in clinical trials, which could provide a simple and direct method for evaluation of vaccine-induced immune responses.
Whereas in general a different objective will result in a different optimal strategy, many simulations have shown that in the control of infectious diseases different objectives can result in similar optimal allocation patterns of scarce vaccines.
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