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The purpose of this study was to apply variable patterns of stimulation to the thenar muscles of the hand in younger and older adults to determine if force production and neuromuscular fatigue effects were similar.
Moreover, we elucidate how a single pathway can specify distinct physiological outcomes: by combining distinct temporal patterns of stimulation with proteomic profiling, we identify signaling programs that differentially respond to Ras dynamics, including a paracrine circuit that activates STAT3 only after persistent (>1 hr) Ras activation.
The simulated and observed responses reveal that the "input-output" response of a complex multicellular tissue to complex patterns of stimulation can be predicted by a systems-based model.
The patterns of stimuli predicted under normal muscle contractions indicated that several territories and tissues developing within the interzone experience specific patterns of stimulation [initially described in 30, Figure 5].
Although there are more possible combinations (i.e. patterns of stimulation) requiring the response 'different' than the response 'same', we employed a selection of stimuli having 'different' as correct response, so that both responses were represented in a similar proportion within each block.
On the other hand, the neurons studied by Branco et al. seem to lack prominently active dendrites, and the kind of selectivity they report can be summarized as a consistently greater somatic depolarization in response to centripetal, rather than centrifugal, patterns of stimulation.
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To identify genes specifically involved in the action of the first stimulation, but not other differentiation processes, we used diverse patterns of stimulations to narrow down the candidate genes.
The local sign could represent an innate disposition or could result from experience the association of the direction of objects in space, as determined by such evidence as that provided by touch, with the retinal pattern of stimulation.
This is achieved by the anatomical arrangement of the motor neurons and by the termination of the corticospinal tract on interneurons, which convey a coordinated pattern of stimulation to the motor neurons.
Exocytosis in adrenal chromaffin cells is strongly influenced by the pattern of stimulation.
We speak of a disposition to assent (or dissent) in response to a pattern of stimulation but this is not quite accurate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com