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PfEMP1 variants mediate adhesion of IEs to different host endothelial receptors, and different binding properties have been associated with distinct patterns of sequestration and pathogenesis [8].
Thus, var gene recombination hierarchies may promote the evolution of PfEMP1 adhesion groups with different patterns of sequestration and disease.
P. chabaudi- and P. falciparum-infected erythrocytes are reported to have properties that promote different patterns of sequestration [ 33, 42, 51, 52] in their respective host species.
The availability of several luciferase variants whose emissions are optimized for detection from deep tissues is currently improving the sensitivity of such approaches to describe the patterns of sequestration in natural or engrafted mouse tissues by populations of parasites.
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One possible explanation for the different pattern of sequestration observed between P. falciparum- and P. chabaudi-infected erythrocytes is that the var multigene family of P. falciparum, which is a component of knobs and is necessary for sequestration of P. falciparum-infected erythrocytes, does not exist in P. chabaudi [ 53].
28 The severity of disease may be exacerbated by both higher parasite burdens and the tissue-specific patterns of IE sequestration.
To investigate the genome-wide binding pattern of the sequestration protein SeqA in Escherichia coli we applied the ChIP-Chip method as described [ 3].
We do not know whether these regulatory mechanisms may be altered in CLDs, although it has been proposed that inactivation of IRP-2 (which is usually highly expressed in macrophages) by RNS may help to explain iron sequestration patterns of macrophages detected in tissues undergoing inflammation [ 125].
Patterns of metabolic demand may influence the susceptibility of neuronal tissue to the effects of sequestration, and resulting manifestations of malarial retinopathy.
We're preparing for the reality of sequestration.
Families will face layoffs because of sequestration, she said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com