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Nonylphenol and coumestrol showed similar patterns of potency, with dual ranges of activation similar to that seen with E2.
The curated data sets were included in CellMiner to associate patterns of potency in the screen with molecular structures of the compounds and molecular characteristics of the cells.
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Like chloro substituted compounds almost similar pattern of potency was exhibited by the bromo substituted compounds (8i, 8j and 8k).
RT112 cells proved to display an intermediate pattern of signaling potency, with the IGF-IR/Akt pathway being activated at very low levels.
Although conventional in vitro assays might have found the panel of NPs to have a pattern of toxic potency similar to what we observed in vivo, such assays would never have revealed the underlying immunopathological mechanism, greatly enriching the hazard identification and hazard characterization of these materials (Clewell 2005).
Substitution with electron withdrawing group also altered potency against HIV-1 RT, halogen groups like chloro substituted compounds (5h, 5i and 5j) followed the pattern in decreasing order of potency ortho > meta > para.
The language itself ranges from the careful elegance of Daniel's monologues to lines that find the startling patterns and potency in the rambling speech of senility.
Several compounds were observed to be cytotoxic at sub-micromolar level and a pattern of increased aerobic potency was observed in cells over expressing POR.
Together, these findings point to a common origin of potency and insolubility rooted in particular amide amide hydrogen bond patterns.
Reconstructing early cleavage stage mouse conceptuses from appropriate numbers of 'corresponding' blastomeres taken from conceptuses with similar patterns of cell division avoids problems inherent in potency testing isolated blastomeres [7], [8].
RAINER MARIA RILKE Giving is the highest expression of potency.
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