Sentence examples for patterns of modifications from inspiring English sources
A major advantage of top-down MS is that combinatorial patterns of modifications that exist on a single histone molecule can be identified [38], which is particularly valuable in outlining the global landscape of PTMs on histone proteins.
Instead, patterns of modifications co-occur within spatially defined chromatin states.
DNA replication poses a significant challenge to histone-modification based memory as patterns of modifications must be faithfully transmitted to daughter DNA strands (Steffen and Ringrose, 2014).
This clustering yields patterns of modifications that can be correlated to the function of the chromatin, such as transcriptional start sites and enhancers, or to the underlying process, such as transcriptional elongation by RNA polymerase II.
Therefore, histones are modified locally and globally through multiple histone-modifying enzymes with different substrate specificities, generating hierarchical patterns of modifications from single promoters to large regions of chromosomes and even single cells.
The recognition of distribution patterns of modifications at both the local (gene) and global (chromosome) levels are usually required to infer biologically meaningful conclusions (Hayashi et al., 2007; Li et al., 2008).
By the mid-nineteenth century, various sources of evidence had accumulated which pointed to the relatedness between species, their common descent, and patterns of modification.
However, the great majority of bulk histones analysed by western blotting or microscopy, are derived from intergenic chromatin and the patterns of modification observed will not necessarily reflect those present across individual genes.
Figure 3a shows the global distribution patterns of modification events in libraries.
The repeated exposure to music did not by itself induce this pattern of modifications.
Primers corresponding to 150 kb from the Xq centromere-arm boundary were also included (site 9) to address symmetry of the pattern of modifications and to assess chromatin environment outside the centromere.
