Sentence examples for patterns of constraint from inspiring English sources

Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation.

Here we explore to what degree these patterns of constraint extend to mammals.

These patterns echo findings in gene sequence evolution, in which different regions of the same protein may show opposed patterns of constraint or positive selection.

In fact, there may be no direct causal relationship between TE abundance and patterns of constraint on the coding sequences of the piRNA machinery distinct from the background effect.

As is well known for protein sequences [ 21- 23], we expect the pattern of evolution in transcription factor binding sites to reflect the particular patterns of constraint under which they function; important regions or residues should be constrained, while unimportant positions may show fixed changes.

These studies motivated by a long-standing argument about the importance of gene regulation in primate evolution (King and Wilson, 1975)—have been important for identifying patterns of constraint on gene expression phenotypes over long evolutionary time scales, and for suggesting candidate loci that might contribute to phenotypic uniqueness in humans or other species.

Considered at a macroscopic scale, this force similarity provides four patterns of constraints in development of muscle architecture in different-sized animals.

A simple numerical model demonstrates how different time patterns of constraints on pricing and capacity policy instruments may lead to different time patterns of efficiency along those implementation paths.

We study the tempo of recent patterns of constraints on human genes grouped by their functional categories and identify which categories are under altered constraints in humans only and which are evolving rapidly in related species.

We identified the evolutionary trends associated with each cluster by considering the patterns of constraints on polymorphic base positions from the GERP-DAF distribution as well as the GERP distribution of all coding positions, and information available from the literature, as discussed below.

The regional profile is distinct, indicating a general pattern of constraint around exons with more profound constrain around exons of essential genes.