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Historically, three patterns of carriage are recognized in humans: persistent carriage, intermittent carriage, and no carriage.
We assess the importance of transmission vs. between-serotype competition in producing the observed patterns of carriage.
Patterns of carriage varied between surveys, but no group A carrier was found after PsA-TT introduction in Burkina Faso, even among those who were not vaccinated because they were too young or old at the time of vaccination or had otherwise missed the vaccination campaign [ 8].
Conversely, in a 10-year follow-up study which included 126 COPD patients, Murphy et al. [ 30] observed two distinct patterns of carriage of P. aeruginosa: a more frequent pattern of short-term carriage followed by clearance of the strain in up to half of episodes, and a persistence pattern of the same strain in a quarter of the episodes.
Similar(56)
The observed pattern of carriage can be interpreted as manifestations of micro-epidemics, that is, clustering of serotype specific carriage in the mixing groups.
One of the goals of the present study was to assess the relative importance of transmission and between-serotype competition in shaping the clustered pattern of carriage.
The results of our analysis describe the micro-epidemic pattern of carriage in a population with a relatively low use of antibiotics.
For viridans streptococci, Enterococci, Staphylococcus aureus and coagulase-negative Staphylococci, a similar pattern of carriage and colonisation was found in both groups.
The pattern of carriage for both infants and mothers was significantly seasonal: in a logistic regression model controlling for serotype prevalence and time point (infant's age) the first two pairs of Fourier terms were found to be (jointly) significant (children: X2 = 25.4 on 4 df, p < 0.0001; mothers: X2 = 16.9 on 4 df, p = 0.002).
Therefore, understanding the patterns of nasal carriage and the preferential colonization by certain genotypes of SA strains in persistent and intermittent carriers will greatly augment our understanding of SA nasal carriage.
Many individuals carry – but do not suffer infection from – potentially pathogenic bacteria such as Staphylococcus aureus and Streptococcus pyogenes, and phylodynamic approaches may provide insights into the spatiotemporal patterns of transmission, carriage and disease.
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