Sentence examples for pattern with mutation from inspiring English sources

Taken together, our data reveals novel underlying mechanism as to why a colorectal tumour with no known activating mutations in KRAS, BRAF or PIK3CA can display a shared gene expression pattern with mutation carriers, and explains resistance to the treatment of anti-EGFR drugs, such as cetuximab.

This appearance is identical to the most common pattern found with mutations or deletions of the LIS1 gene.

Their interaction with other tissue-specific transcription factors and their spatiotemporal expression patterns, together with mutations in the HMG domain, allow different Sox transcription factors to specify their target selection [1], [8], [9].

Many human neoplasias display an altered epigenetic pattern, with overexpression or mutations of histone modifying enzymes and increased promoter methylation, leading to silencing of tumor suppressors [ 33].

Gene expression studies have also been used to differentiate benign from malignant thyroid tumours, and correlate gene expression patterns with specific mutations or rearrangements in PTC and FTC (for review, see Eszlinger et al, 2007).

Together our data suggest that specific genome-instability mutations are sufficient to drive discrete mutational signatures, some of which share properties with mutation patterns seen in tumors.

How does the mutation data reported here compare with mutation patterns or frequency seen in other populations?

Co-variation analysis and site-directed mutagenesis showed a relatively conserved pattern of MPER substitutions associated with mutation at position 680, but also revealed that residues outside the MPER are important in conferring the 4E10-resistant phenotype.

In ATLD patients (Mre11 deficient), we did observe a perturbed mutation pattern, with a small increase of A to C transversions (phase II).

A similar pattern of mutation segregation with mosaic respiratory chain deficiency is seen in patients with mitochondrial disease syndromes caused by inherited pathogenic mtDNA mutations.

The pattern is correlated to genomic features, with mutation densities greatest in regions predicted to have high superhelicity.