While variants with a consistent advantage are likely to go to fixation quickly, variants with intransitive patterns of success against different competitors are likely to be retained in populations.
Morphologic variants with a diffuse pattern or an abundant reactive T cell infiltrate mimicking T cell/histiocyte rich B cell lymphoma (THRLBCL) have been described [ 4, 5].
A pattern is a design structure consisting of a core specification, i.e., an invariant composition of WebML elements that characterizes the pattern and by a number of pattern variants which extend the core specification with all the valid modalities in which the pattern composition can start (starting variants) or terminate (termination variants).
The possibilities were not really discussed that convergent evolution, human bias during manual sequence alignment, or other alignment or interpretation troubles led the authors to produce a catalog of pattern 3 variants with relatively little value for guiding the interpretation of clan AA protease evolution.
The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and patterns of these variants with high sensitivity.
The different tissues of origin provide for non-overlapping patterns of ENOX2 protein transcript variants each with a characteristic number of protein transcript variants, molecular weights and pIs.
This is not surprising because these predictive methods heavily rely on the evolutionary patterns of variants associated with Mendelian diseases, which are under strong purifying selections across species [ 28, 29].
Thus, we provide a unified framework for the analysis of one or more variants with any pattern of linkage disequilibrium and with any minor genotype frequency.
Interestingly, using the Biolog characteristics, the group ST-21 strains could be largely subdivided into two phenotypic variants with characteristic patterns of properties.
Our alternative hypotheses of selection begin with a working null hypothesis that assumes no historical selective differences among Nsp variants, with current patterns of genetic variation at Nsp solely reflecting demographic effects such as population structure or historical population expansion (H0-demography).
