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A conformational pattern, specific for each allele, has been observed, evidencing that the tridimensional structure of the presented epitope is not solely an intrinsic characteristic of the epitope itself (i.e. due to the amino acid sequence per se), but is actively determined by the MHC-I cleft, which varies according to the MHC allele (Figures 1 and 2).
Thus we got the significant inverse expression pattern specific for the gastric cancer.
As a result, we identified a distinct molecular activation pattern specific for the activation state of human nTregs.
Although there were some carbohydrates to which we could detect higher reactivity in some of the patients with RA than in the controls (such as Gal(a), Man(a) and GlcA (b), Gal(b1-3) [GlcNAc(b1-6)] GalNAc (a)), we could not identify a clear carbohydrate recognition pattern specific for RA (data not shown).
As noted in the results, in some cases the metabolite profiles from the compound treatments in this study had already been used in the development of the metabolite pattern specific for a mechanism of action, and as such, matches between the profile and the mechanistic pattern would be expected.
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However, no ECG findings or patterns specific for IVNC were found.
In conclusion, the respiratory network has rhythmogenic capabilities at multiple levels of network organization, allowing expression of motor patterns specific for various physiological and pathophysiological respiratory behaviors.
Analysis of the ORF3 RT-PCR products, digested with SmaI, RsaI and AccI restriction enzymes revealed four distinct patterns specific for the three species.
Although intraventricular conduction delay, repolarization abnormalities, and LV hypertrophy are frequently present, no ECG patterns specific for IVNC at the first presentation with the disease were found.
Most of these transcripts showed expression patterns specific for the defined stress conditions that we tested.
The rationale behind analysing well-supported clusters of country-specific sequences (instead of analysing all country-specific sequences together, regardless of clustering) is that it gives the highest probability of extracting demographic patterns specific for the country under study, without any influence of sequences from other countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com