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The event should fit a pattern ("signature") of liver chemistry elevations observed in other patients treated with the study drug but not the comparator.
Therefore, fungal LysMs can be phylogenetically separated into different clades based on their aa-sequences and these differences are reflected by a characteristic cysteine pattern signature.
The patterns of any two individuals, paired or non-paired, were highly dissimilar, including those whose same sides were examined and those whose reciprocal sides were examined, suggesting that each individual in this species possesses a unique side pattern signature.
The proof of identity can be one or a mix of the following: 1) what the user knows (eg, password, PIN, pass phrase, or challenge response where the user must answer a question); 2) what the user has (eg, security token, ID card), 3) what the user is or does (eg, finger print, retinal pattern, signature, voice, face).
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Such strong blocking pattern signatures may be associated with an incoming deep solar minimum period similar to what we experienced between 2008 and 2011, which helps to flush more cool to cold air into the middle latitudes during the winter seasons mainly (record snows in Europe and a very cool North American March to April period).
CHFs have been employed for defining of rotation-invariant pattern signatures.
The pattern signatures were partitioned into classes based on their length.
Currently, the classifiers of disease etiology and prognosis utilize SNP, microarray, proteomic and metabolomic data aligning particular pattern signatures with clinical correlates [24], [25].
Pathogen associated molecular pattern signatures for pathogenic mycobacteria include, CpG DNA, 19 kDa lipoprotein, lipoarabidomannan and mannosylated phosphotidylinositol (PIM) [ 8].
Further, multiplexed phenotyping that involves parallel measurements of CD antigens can help identify expression pattern signatures that are associated with specific disease states [ 51].
Increasingly biomedical studies require a top-down approach that can be achieved by comparing patterns, signatures or "fingerprints" of metabolites that change in response to disease, toxin exposure, environmental or genetic alterations.
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