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The approach is based on graphs, morphisms and operations from category theory and exploits triple graphs to annotate model elements with pattern roles.
We further allow mapping of individual design pattern roles to (parts of) implementation elements to be generated (e.g., classes, methods) and check the conformance of the realization with the specification of the pattern.
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tsh also has Hox-independent patterning roles throughout Drosophila development.
Consistent with the multiple patterning roles of Hh signaling, dysregulation of any of these events can have severe physiological consequences.
A better understanding of instructive patterning roles for this important neurotransmitter will significantly impact our understanding of neuropharmacology and the etiology of a wide range of birth defects.
Given their important patterning roles, Hox genes are thought to have strongly contributed to morphological diversification of bilaterian organisms during evolution.
LIM homeobox (Lhx) transcription factors are unique to the animal lineage and have patterning roles during embryonic development in flies, nematodes and vertebrates, with a conserved role in specifying neuronal identity.
Our data suggest that most genes are conserved in their tarsal patterning roles between D. melanogaster and T. castaneum, but that several have undergone changes in the PD extent of activity.
In this context, other HD-containing determinants could play important patterning roles (de Jong et al., 2006), as demonstrated for Six transcription factors in the early specification of the aboral pole (Sinigaglia et al., 2013).
The impressive "Nails" (1978) is a large wall hanging of brown, gray and white tones in cloth, metal and plastic whose materials play a patterning role, quirkily inflected by geometric and linear elements.
Due to the strong requirement for hairy in early embryonic patterning, it was necessary to distinguish hairy function in tracheal development from its earlier patterning role.
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