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337 In contrast, the role of adverse environment (eg, nutrition, physical activity, cellular stress, pharmacotherapy) during postnatal growth and adulthood for the modification of the epigenetic pattern remains a matter of debate.
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Why we should observe this pattern remains an open question.
However, the regulatory mechanism that causes the hourglass pattern remains an open question.
Despite this caveat, the Th1/Th2 cytokine pattern remains an effective, although over-simplistic, model of representing the intricate relationship between immune abnormalities characteristic of autoimmune rheumatic diseases and immune regulatory changes induced by pregnancy.
Yet, explaining precisely how these patterns form remains a challenge.
Stability of crime patterns remains a key issue in spatial criminology due to its theoretical and policy implications.
However, the biological significance of this patterning remains a question.
Among others, the relationship between our learning-based theory and evolutionary processes that shape animal a priori preferences and influence behavioral patterns remains a key challenge.
The assignment of functional information to these complex patterns remains a challenging task in effectively interpreting data and correlating results from across experiments, projects and laboratories.
While genome sequencing and microarray approaches have provided important insight into the biology of prokaryotic organisms, including a number of human bacterial pathogens, identification of all genes and their transcriptional patterns remains a major challenge in all areas of biology.
Of the second-generation methods evaluated for S. enterica Enteritidis subtyping, multilocus variable number tandem repeat analysis offers slightly better discrimination, but differentiating common patterns remains a substantial problem (6 ).
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