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Taken together, this strategy has two advantages: (1) inserted exogenous genes can faithfully recapitulate the expression pattern of targeted endogenous genes; (2) the expression and function of targeted endogenous genes are maintained.
Sequence variations present in the seed region (7 8 nt of the 5′ end of mature miRNA), which is responsible for miRNA binding to 3′-untranslated region of target messenger RNAs, influence miRNA functions by changing the pattern of targeted genes, and can also affect susceptibility to cancer (1, 3, 5, 26 28).
The findings, coupled with in-depth interviews and forensic medical examinations of Rohingya survivors, point to a widespread and systematic pattern of targeted violence – including rapes and killings of women, men, and children – that drove more than 720,000 Rohingya into neighboring Bangladesh.
Moreover, the Obama administration's pattern of targeted killings in the war on terror establishes an important conceptual point.
One prerequisite is the accurate measurement of the labeling pattern of targeted metabolites.
Through this strategy it is easy to see the pattern of targeted legislation and interventions in cases (such as the recent foetal alcohol syndrome case) that could set legal precedents to muddy the waters around abortion.
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The documents show a pattern of targeting Correa's intellectual and political opponents in the media, indigenous movements and parliament.
This demonstrates a systematic and deliberate pattern of targeting minority Shia Muslims by militant groups including Lashkar-e-Jhangvi and Ahle Sunnat Wal Jamaat, formerly known as Sipa-e-Sahaba.
In a separate development – but one that church leaders say is part of a pattern of targeting Christians – Jerusalem city council issued churches with a demand in February for nearly $200m£143m3m) in back taxes.
But both attacks on Friday fit a Taliban pattern of targeting Afghan security forces as the American-led coalition pulls back from front-line positions and shifts to a support role.
Additionally, unlabeled anti-CEA scFv-Fc(H310A) was injected into CEA-positive tumor bearing mice and ex vivo IHC was performed to identify the presence of the antibody to define the microscopic intratumoral pattern of targeting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com