Suggestions(2)
Exact(24)
Sammeth et al. developed a notation that assigns a unique code to every possible pattern of splicing variation [14].
These RNAs are aberrantly spliced in adult DM1 hearts and retain the pattern of splicing observed in new-borns [36].
Recent studies indicate that the pattern of splicing of exonized TEs differs among human tissues [25], [26], [27].
This is in line with studies describing that Snail1 changes the pattern of splicing of p120-Catenin and Zonula occludens-1 by uncharacterized mechanisms [31], [32].
Although these solutions are very useful to classify and describe patterns of splicing events, they do not directly address the problem of identifying the transcripts produced by those events in a general and exact way: there may easily be isoforms produced by the same pattern of splicing events that generate very different transcripts.
This led to the acquisition of a complex pattern of splicing variants.
Similar(36)
CD44 shows an unusual pattern of splice variants in mammary tumorigenesis, which arises from the differential usage of 10 internal exons.
This possible splice change cannot be the single primary functional effect, as rs4821480 is not significant when conditioned on rs2413396, but it could contribute to a more complex pattern of splice and possibly expression variation.
Mutations at splice sites may also modify patterns of splicing in a deleterious way.
(31, 32) Mutations of individual splicing factors also show particular patterns of splicing in specific gene subsets.
Selection of splice sites was not random since different patterns of splicing were observed in the root and shoot tissues.
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