Suggestions(2)
Exact(6)
However, inoculation alone could not account for the simultaneous shift in the age pattern of smallpox in children, most of whom would have been London-born.
85 The changes in the age pattern of smallpox mortality in Geneva are strikingly similar to those evident in the St Martin's population earlier in the 1770s, and consistent with the diffusion of a novel viral strain.
With respect to the impact of smallpox on death rates outside the metropolis, our analysis indicates, together with Razzell's evidence of a north south divide, a geographically uneven pattern of smallpox epidemics and susceptibility in the period before 1775.
However, we also discovered a very abrupt shift in the age pattern of smallpox burials to younger ages in the 1770s, in both St Martin's, Westminster, and St Dunstan's, Stepney.
83 As another type of internal check, we compared burials attributed to smallpox with those attributed to measles, which indicated that changes in the age pattern of smallpox burials could not be attributed to changes in the underlying age structure of the population at risk.
65 In addition, rural inoculation should not have affected the age pattern of smallpox mortality among children in London, whereas an increase in transmission of smallpox should have reduced the average age at infection in rural areas, and could have had a similar effect in London, if the same processes were at work in the metropolis.
Similar(54)
Therefore we used several methods to test whether the observed patterns of smallpox burials reflected 'real' changes in smallpox mortality rates and age patterns.
Section II describes the patterns of smallpox mortality in St Martin's, in particular the rapid decline in adult smallpox burials after c. 1770.
However, very few smallpox burials were in the highest quintile of burial fees, so this particular group of migrants cannot account for the curious patterns of smallpox burials by sex and status before the 1770s.
The mummy had vesicular cutaneous lesions distributed in a pattern characteristic of smallpox.
A contact pattern model of smallpox spread found that outbreaks could be contained by targeted vaccination combined with early detection without resorting to mass vaccination [ 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com