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The finding that asbestos exposure is associated with a significantly different pattern of signalling dysregulation in NSCLC supports the notion that clonal selection has important nodal points that are influenced by the pattern of carcinogen exposure.
This is in direct contrast to the pattern of signalling observed with normal activated EGFR receptors which signal equally through both the Ras and Rap1 pathways.
Analysis of the pattern of signalling proteins production in SRMA showed many similarities with results in KD supporting the usefulness of this animal model.
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The initial pattern of signaling appears to be established by early, more global embryonic patterning systems.
Collectively, these findings in rodents suggest a complex, compartmentalized pattern of signaling that appears to be highly dependent on experimental conditions and timing.
In the pattern of signaling, three subclasses of GBM emerge which appear to be associated with predominance of EGFR activation, PDGFR activation, or loss of the RAS regulator NF1.
This generates the same pattern of signaling in all classes of ganglion cells, which is not the norm.
We studied the pattern of signaling interactions across the IT pathway proteins using the data set reported by Cui et al. (2007).
RT112 cells proved to display an intermediate pattern of signaling potency, with the IGF-IR/Akt pathway being activated at very low levels.
Our results are similar to that of Morrows et al., [ 41] who observed different patterns of signalling in colon tumour cell lines harbouring the same mutation.
Figure 9 shows the time-course patterns of signaling molecules in this sensitivity analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com