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This study aimed to evaluate the pattern of sensitization towards five peanut allergenic components (rAra h 1, 2, 3, 8 and 9) in a population of Italian children and adolescents with specific IgE (sIgE) to peanut.
As shown from the Italian observational survey "Pan-allergens in Pediatrics," children living in the Northern Italy have peculiar pattern of sensitization against plant-derived allergens (e.g., grasses, birch, hazel tree, and peanut) which differs from the population of the South of the peninsula [ 21].
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There appear to be different patterns of sensitization due to varying allergens in different indoor settings.
To our knowledge the dynamic process of development of specific IgE-ab against the most common inhalant allergens over time, in terms of patterns of sensitization and specific IgE-ab concentrations, has not been as thoroughly described before [ 26].
To identify frequency and pattern of contact sensitization among patients with periorbital dermatitis.
This form of sensitization is related to changes in the properties of primary nociceptive afferents (peripheral sensitization), whereas central sensitization requires functional changes in the CNS (neuroplasticity).
This form of sensitization has been variously referred to as "conventional" or "nociceptive" sensitization [ 39] or "extrinsic" sensitization [ 10, 27, 37, 42, 48, 49].
Similarly, recordings of neural activity in nociceptive-specific and wide dynamic range cells in the trigeminal caudalis (Vc) show patterns of increasing activity (sensitization) when capsaicin was delivered at short ISIs (<1 min) and decreasing activity (desensitization) when delivered at longer ISIs (>5 min; [23]).
Degree of sensitization.
The mechanism of sensitization and activation is established.
Recently, skin sensitization has been formulated as an adverse outcome pathway (AOP) to address the complex nature of sensitization [19].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com