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He was doing groundbreaking work on the pattern of replication of bone marrow cells.
We found that the pattern of replication timing in and around the R/G band boundary at 11q13.5/q14.1 was similar in CHO h11) cells and fibroblasts.
The sparser pattern of replication in superficial nuclei might be due to a slower or intermittent suprabasal DNA replication.
It was found that cells with impaired function of thymidylate synthase (ThyA) seemed to exhibit a changed pattern of replication fork organization [24].
The result shows that cells, when treated with HU, acquire a changed pattern of replication (longer C and more forks), but the distribution of SeqA foci does not change significantly.
Recent studies have begun to elucidate the pattern of replication timing on a genomic scale.
Similar(43)
We next asked whether there are associated patterns of replication timing alterations in other cancer cell types.
Complex and incompletely understood patterns of replication of mitochondria in the developing embryo mean that it is rarely possible to predict accurately the severity of mitochondrial diseases.
Each of the non-cancer patients showed the expected synchronous patterns of replication for each of these loci.
The GOstat results in Table 5 give us an indication that there are temporal patterns of replication for some functionally related genes.
However, it should be emphasized that the cancer-based aberrant patterns of replication are not age dependent, as they characterize young cancer patients as well as elderly ones [ 35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com