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The pattern of regulatory coordination is dependent on the composition of the miRNA cluster.
Overall, the data imply that each pattern of regulatory innovations yielded diminishing adaptive advantages over time and eventually became exhausted.
A function f k represents a pattern of regulatory interactions that drive the expression of the k-th gene.
It remains to be elucidated why a particular pattern of regulatory changes continued for hundreds of millions of years.
The pattern of regulatory changes during a particular period of vertebrate evolution probably drove new biological adaptations.
Our analysis shows that for each module there is a pattern of regulatory motifs present in nearly all promoter regions that distinguish it from the other modules.
Similar(44)
Gene regulatory circuits with different architectures (patterns of regulatory interactions) can generate similar dynamics.
We conclude that the patterns of regulatory discourse practices of the place emerge from the hybridity and amalgamation of globally-uniform and locally-endemic resources which are transculturally mobile and which are relocalized bidirectionally.
By analyzing expression patterns of regulatory DNA driving reporter genes in different genetic backgrounds, we identify a key component of this system by showing that WG directly represses transcription of the dpp gene in the ventral leg disc.
However, our extended analysis of regions accelerated in non-human mammalian genomes also enabled us to reveal that PFO vs. PT differentially expressed genes are additionally enriched for patterns of regulatory change in the chimpanzee and mouse lineages.
A limited number of studies have investigated alterations in the expression patterns of regulatory genes in developing tissues in vivo in response to immobilisation, showing for example alteration in FGF2 [37], IHH and COLX [22].
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