Sentence examples for pattern of mutational events from inspiring English sources

EGFR, the second most recurrently mutated oncogene in lung adenocarcinoma, showed a much more dispersed pattern of mutational events across its protein-coding domains.

Because such changes are accompanied by large changes in gene content, they often have a substantial effect on organismal fitness and highly variable fixation probabilities, and therefore, their incidence cannot fully portray the underlying pattern of mutational events.

These point mutations were compared with a genome-wide collection of high-quality SNPs to assess whether these two datasets of mutational events show similar patterns in terms of distribution and surrounding sequence contexts.

Mutation clustering may arise due to the coordination of mutational events or as part of hotspots of mutation.

The patterns of natural variation found in a genome are the result of mutational events that are influenced by both drift and selection.

The timing of mutational events during tumour evolution presents diagnostic, prognostic and therapeutic opportunities.

However, random mutagenesis, used in TILLING approaches, provides only a limited density of mutational events at a defined target locus.

Because of the vast number of mutational events, it is difficult to demonstrate that any particular growth factor signaling pathway is critical.

We suggest combinatorial summary of mutational events.

Several types of mutational events are allowed.

Computational inference of mutational events leading to DIMs also has limitations.