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Plasma cells from subjects with active SLE manifest extensively mutated VH and VL genes, and the pattern of mutation is comparable to that noted following T cell-dependent antigen stimulation [ 14- 17, 44- 468]68].
Similarly, the RNAse1 gene of ruminant artiodactyls and colobine monkeys is homologous in that the RNAse1 gene is present in the common ancestor, but the gene was duplicated independently in each group (Fig. 2), and each lineage has subsequently evolved a new, yet parallel, function for this gene, without sharing the same pattern of mutation and amino acid substitution (Zhang 2003).
Zhidkov et al [47] suggest that these alterations form a pattern of mutation that can be traced to ancient phylogeny.
On the other hand, in view of these results it is hard to entertain the possibility that the true pattern of mutation is one of a main 4×4 matrix with only one or very few neighbor-base-dependent effects.
The exact pattern of mutation rate variation in rice is unknown.
No particular pattern of mutation or deletion was found in this part of FCoVs genome.
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For the T[5-Me,8]G cross-link, a similar pattern of mutations was noted, but the mutational frequency was significantly higher than that of G[8,5-Me]T.
For the T[5-Me,8]G cross-link, altheugh the mutational frequency increased, a similar pattern of mutations was noted.
In this study, we investigated the frequency and pattern of mutations in the D310 region, the most commonly mutated region in mtDNA, in a series of breast lesions.
The pattern of mutations in the U.S. field isolates suggests that the U.S. strains are slowly drifting away from their progenitor Line 0-like sequences.
The pattern of mutations in mitochondrial DNA is often used to estimate how long ago separate populations diverged and roughly what racial group that individual belonged to.
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