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Single-nucleotide variations (SNVs) exhibited a pattern of localized hypermutation called kataegis in 50% of the tumors.
The method accepts as a premise that such slabs form a pattern of localized yield lines as an initial small-deflection failure mechanism, and that these yield lines retain their positions as subsequent deflection occurs.
By pausing the focused beam of different energy for different amounts of time at different locations, any pattern of localized damage can be built up.
First, all α-particles emitted by radionuclides, irrespective of their source, produce the same pattern of secondary ionizations and the same pattern of localized damage to biological molecules, including DNA.
A pattern of localized retinal nerve fiber layer defects in glaucoma patients indicate that axonal degeneration may precede RGC body death in this condition.
Leaf mesophyll cells start to senesce first, followed by other cell types, and exhibit an incoherent pattern of localized cell death, which eventually spreads to the whole leaf.
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TrxG complexes and PcG complexes maintain the expression pattern of genes localized in appropriate domains [ 61, 62].
The visualization of the shape differences on the mandible using geometric morphometric methods indicated a spatial pattern of variation localized to specific parts of the mandible rather than to the mandible as a whole.
In the current study, the observation of a disorganized pattern of nuclei localized to the equatorial bow region of alphaA/BKO lenses, and nucleic acid staining of structures throughout the anterior cortex of 54 wk alphaA/BKO lenses, is consistent with a role for alpha-crystallin in the nucleus.
The α8β1 integrin binds to fibronectin, vitronectin and tenascin-c, yet none of these proteins are expressed in the appropriate spatiotemporal pattern to localize to the site of kidney development.
Overall, clustering of transcription patterns based on chromosome localisation (PC) did not reveal major differences between the transcription patterns of genes localized on atypical chromosomes and other chromosomes (Fig 3B).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com