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Each record was divided into three intervals of records: morning, day, and night intervals; and was inserted into one of three sets according to the temporal pattern of ischemia: salvo, periodic, and sporadic pattern.
The quantity and severity of occluded vessels at different time points observed by histology suggested a pattern of ischemia that is likely detectable grossly in whole brain.
Figure 4 shows a repeating pattern of ischemia at 36-hours after protein diet exposure in Gcdh−/− mice, which consistently showed pale ischemic regions of cortex and striatum bilaterally.
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The results support the hypothesis that there are at least two distinct populations, which differ according to mechanisms and temporal patterns of ischemia.
From that study and the present data, it appears that during severe hemorrhagic shock cerebral energy metabolism is severely compromised exhibiting a biochemical pattern typical of ischemia.
This experimental study documents that during protracted (≈90 min) and pronounced (MAP≈35 mmHg) hemorrhagic shock, cerebral energy metabolism was severely compromised and exhibited a biochemical pattern typical of ischemia, energy failure, and cellular degradation.
This experimental study documents that during protracted pronounced hemorrhagic shock, cerebral energy metabolism was severely compromised and exhibited a biochemical pattern typical of ischemia and cellular degradation.
This metabolic pattern is characteristic of ischemia (i.e., a simultaneous decrease in tissue oxygenation supply and substrate/glucose) [8 10].
Finally, no GPR17 co-expression was found in resting microglia detected by anti-Iba1 staining in the intact brain (Figure 2K) (however, see: "Expression pattern of GPR17 during ischemia evolution").
Their expressions were subsequently quantified by real-time reverse transcription polymerase chain reaction (real-time RT-PCR) to determine their expression pattern after different durations of ischemia and reperfusion.
33 Hoping to provide more accurate information upon the tibial runoff and the collateral reserve in each critical limb ischemia pattern of presentation, Mustapha et al 34 recently proposed an original classification and interventional protocol for AM-guided below-knee interventions.
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