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This pattern of duplication is often called 'duplication shadowing' [ 33] as the duplicated sequences tend to cluster in the region along with an ancestral copy.
The pattern of duplication did not show significant difference among the global variant populations (Fig. 4).
The pattern of duplication for APBA2 adds to a complex mosaic including many duplicon-like structures in 15q13.
Based on the pattern of duplication, we have constructed a model indicating how the Fox cluster locus evolved in vertebrates.
This pattern of duplication might be resulted from part of the two rounds of genome duplication in vertebrate ancestry [ 6].
Five genes (ZNF426, ZIK1, HLA-SX-alpha, PNMA5, PNMA3) have in-paralogs in the reference species suggesting a pattern of duplication event (Additional data file 6).
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In contrast to previous reports of duplications involving the control regions of other animals, this particular pattern of duplications appears to be unique to P. cantorii.
Overall, Rab11 presents a unique pattern of duplications.
The two previous published phylogenies disagreed regarding the pattern of duplications.
Even though most of them do show a repeated pattern of duplications, which are accompanied by tissue-specific expression, this is not the case for all of them.
It would therefore be interesting to investigate whether the pattern of duplications and diversifications found for the Rab family in fungi [ 39] correlates with that of the SNARE family [ 22].
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