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This would counter the tendency of eGFRcreat to underestimate renal function and result in the symmetric pattern of discordance in the FinnDiane cohort.
A balanced pattern of discordance was seen among the remaining samples with 23.9% of model estimated concentrations in higher percentile categories than measured concentrations, and 21.6% of modeled estimated concentrations in lower percentile categories than measured concentrations.
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Patterns of discordance between the two PIPS subscale scores deserve further study.
Our correction technique involved using the empirically observed patterns of discordance in matched gDNA and wgaDNA samples from cases to adjust the estimated ORs for the associations between each of these SNPs and the risk of ALL.
Last, consistent with the observation that deep coalescences appear to influence the H. formosa mtDNA/gene tree (e.g. Figure 6B), patterns of discordance between markers herein may to some extent reflect historical processes of incomplete lineage sorting in addition to the homogenizing effects of gene flow [significant when Nm > 4 (reviewed in [ 29]), as in H. formosa].
The geographic scale and complex pattern of the discordance implicates the remaining explanations.
In the present study, we analyzed the pattern of KRAS discordance (i.e. from WT in primary tumors to MT in related metastatic sites or vice versa); as the sample size was small (N = 25), the KRAS discordance pattern did not show any relation to clinical situations for the development of systemic metastasis (stage IV vs. recurred) or metastatic organs from which tumor specimens were obtained.
The nested pattern of the discordances prevented us from testing their individual significance by using the classical method of removing all discordant taxa and then adding them individually in comparative tests (see [ 39] for an example).
The remaining 40% (18/45) specimens showed various patterns of subtype discordance in different regions of HIV-1 genomes indicating 2-4 cirecombinantecombinant subtypes derived from clades B, F and C.
The asymmetric pattern of the observed discordances indicates that the shift is non-random (p = 0.06, McNemar-Bowker test of symmetry).
The X-chromosome inactivation pattern and/or BRAF status had the same rate of discordance in patients with lymph node metastasis (3/9, 33.3%) and in patients without metastasis (1/3, 33.3%).
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