After in vitro exposure to Infliximab, there was a lack of effector cells, suggesting that this drug might block the lineage pattern of differentiation (naive → memory → effector → terminally differentiated cells), as a consequence of expansion and activation inhibition.
Instead, Wnt1-induced luminal cells "retro-differentiated" to basal cells (reversing the usual basal-luminal pattern of differentiation).
In general, early cancers resemble their tissue of origin and are described and classified by their pattern of differentiation.
This comparison reveals the commonality in the general pattern of differentiation, but also the differences among species in the sequence of appearance of structures.
Neuroblastoma is one of the peripheral neuroblastic tumors (pNTs) that have similar origins and show a wide pattern of differentiation ranging from benign ganglioneuroma to stroma-rich ganglioneuroblastoma with neuroblastic cells intermixed or in nodules, to highly malignant neuroblastoma.
A similar pattern of differentiation was found for a population sampled on the exposed side of Davies Reef [45].
In addition, the pattern of differentiation of the secondary fiber cells at the equatorial region was abnormal, and there was evidence of disorganization in the cuboidal epithelial cells.
The addition of FGFs 4 or 8 in combination with BMP4, however, failed to change the differentiation outcome or gene expression pattern of differentiation.
We first examined the temporal pattern of differentiation of ESNPs transplanted to the DG in animals that had experienced prior seizures.
Rather, the pattern of differentiation of the populations studied appears to be linked to potential dispersal barriers created by ancient ridges also called palaeoarches [see Figure 1, after [26]].
This pattern of differentiation in which cells in the surrounding monolayers were almost all Prdm1-positive and a fraction of the cells were MyHC-expressing myocytes was seen consistently in nine independent explants treated with the control oligonucleotide.
