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To characterize the pattern of cell proliferation and apoptosis of eutopic and ectopic endometrium in rabbits after endometrium implantation for the experimental induction of endometriosis.
The pattern of cell proliferation along the heart tube was perturbed in either case, suggesting that differential rates of cell proliferation are important for proper looping to occur.
Together these results demonstrate that tbx3b and tbx2a are crucial for the establishment of the dynamic pattern of cell proliferation in the heart tube and further show that perturbation of this pattern may have drastic consequences for heart looping.
Since the AVC constriction is unusually wide in Tbx3-null mutants and there is ectopic activation of the chamber genetic program, we analyzed whether the pattern of cell proliferation was altered in these mutants.
Analysis of the pattern of cell proliferation along the extent of the zebrafish heart tube revealed that cell proliferation is dynamic throughout heart development, increasing upon initiation of chamber formation (this study).
Thus, a dynamic pattern of cell proliferation along the heart tube accompanies chamber outgrowth, and a crucial differentiation step occurs at 33 hpf, concomitant with the rightward jogging of the future ventricle.
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These findings also suggest that the spatiotemporal patterning of cell proliferation and the Shh expression areas in the epithelium regulate the crown width and cusp formation of the developing tooth.
Our results confirm previously established patterns of cell proliferation, survival, and migration during the first month after BrdU injection [29], [30].
To explore cellular processes impacted by mechanical stimulation, patterns of cell proliferation in the distal femur were compared between immobilised and control specimens.
The lens was chosen because a) metabolism in lens epithelia is comparable to that of cells in many other tissues, b) to avoid embryonic lethal effects that might affect critical organs, c) aberrations in the proteome might lead to readily observed opacity, and d) because patterns of cell proliferation and differentiation are well documented and readily observed.
This article examines the current understanding of both mechanisms by which chemicals provoke cell proliferation and the contribution of various kinetic patterns of cell proliferation to carcinogenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com