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To examine the molecular detail of its defect, we examined the pattern of cell cycle marker such as BrdU staining or that of ecdysone receptor subtypes (EcR-A, 15G1a; EcR-B1, AD4.4; or EcR-common, Ag10.2) in the mutant tissues, but no apparent abnormality was observed (data not shown).
Interestingly, the temporal expression pattern of cell cycle genes described above was altered by NCS treatment.
This study evaluates the expression pattern of cell cycle proteins involved in the G1/S transition in a large amount of RCC, using the TMA technique and immunohistochemistry.
Saffron extract induced a p53-dependent pattern of cell cycle distribution with a full G2/M stop in HCT116 p53 wildtype cells.
These results, taken together, indicate that the pattern of cell cycle arrest depends on the cell type and not on the specific garlic component used.
Since the balance between DNA repair, neuroplasticity and neurodegeneration may change depending on disease stage, it can be argued that each AD stage could be characterised by a specific pattern of cell cycle protein expression in post-mitotic neurons.
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Recently, overexpression of AP-2α in pancreatic cancer cells was shown to reduce tumor growth through an altered expression pattern of cell cycle-controlling factors such as CDK-4, CDK-6, cyclin-G1, p27kip1 and p57kip2 [22].
Overexpression of AP-2α in pancreatic cancer cells was shown to reduce tumor growth through an altered expression pattern of cell cycle-controlling factors such as CDK-4, CDK-6, Cyclin-G1, p27kip1 and p57kip2 [22].
An altered expression pattern of cell cycle-controlling factors (CDK-4, CDK-6, cyclin-G1, p27kip1 and p57kip2) was observed in AP-2 α-overexpressing clones by microarrays and western blot analysis.
The purpose of our study was to investigate the expression patterns of cell cycle regulatory proteins and members of the epidermal growth factor receptor (EGFR) signaling pathway in squamous cell carcinoma of the head and neck (HNSCC).
It is conceivable, however, that such subgroups differ in their patterns of cell cycle dysregulation.
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