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Recent advances in microarrays have enabled large-scale analysis of copy number changes in tumor samples (43), and massive sequencing has identified the pattern of breakpoints in a large panel of cancer cell lines (28).
Interestingly, for 11 of these 79 confirmed deletions we did not find a pattern of breakpoints as expected from the large simple deletions or the deletions associated with insertions.
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It is also important to mention that the pattern of recombination breakpoints produced in our system with one conditional centromere and one natural centromere may be different than recombination events induced in a chromosome with two natural centromeres.
Besides its presence in the 10,000 bp sequence, the unusual pattern of translocation breakpoint sequences linked to high A + T regions is also found in other regions of 22q11.2.
We examined hysteresis effects in the models by determining patterns of worm breakpoints and system shifts to alternate stable zero- or endemic infection states as initial L3 values are varied [21].
The alignment patterns of such "breakpoint reads" were used to infer the type and size of polymorphism.
The overall data provide information about the frequency distribution of RCI tract lengths, the pattern of distribution of their breakpoints on the cytogenetic map, and their geographic distribution in An. gambiae.
Χ2 = 13.08; P = 0.0014 The nonrandom pattern of distribution of RCI breakpoints mirrors that of the common polymorphic inversions in the An.
The simulation process resulted in different lengths, locations of breakpoints, and patterns of rare alleles for each founding haplotype segment.
The lack of any deletions or duplications and the pattern of TSDs in the 2z3 breakpoints allow us to reject this latter possibility.
In another study, Bansal et al. [ 24] used the linkage disequilibrium (LD) pattern of SNPs to map putative inversion breakpoints.
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