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Alzheimer's disease (AD) shows a characteristic pattern of brain atrophy, with predominant involvement of posterior limbic structures, and relative preservation of rostral limbic and primary cortical regions.
Understanding the pattern of brain atrophy in T2DM may provide clues toward the underlying neurodegenerative process.
Our data indicate that there is no topologically consistent cortical structural alteration or generalized pattern of brain atrophy underlying persistent postoperative seizures.
The aim of our study was therefore to determine the pattern of brain atrophy associated with C9ORF72, and to determine which regions best differentiate C9ORF72 from MAPT and GRN, as well as from sporadic FTD including ALS.
We aimed to determine the regional pattern of brain atrophy associated with the C9ORF72 gene mutation, and to determine which regions best differentiate C9ORF72 from subjects with mutations in tau and progranulin, and from sporadic frontotemporal dementia.
Another key observation from the new study is that the pattern of brain atrophy that is observed in type 2 diabetes is similar to the one in early Alzheimer disease.
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To determine overall patterns of brain atrophy associated with memory, executive function (EF) and dopamine non-responsive motor measures in older parkinsonian patients.
Statistical maps revealed 3D patterns of brain atrophy at each follow-up scan relative to the baseline; numerical summaries were used to quantify temporal lobe atrophy within a statistically-defined region-of-interest.
Different patterns of brain atrophy were described by Burton et al. [ 49].
Nonlinear fluid registration of follow-up to baseline scan was performed to visualise longitudinal intra-subject patterns of brain atrophy and ventricular expansion.
Moreover, studies including our own have also shown heterogeneous patterns of brain atrophy exist in MCI subjects that convert to AD and those who remain clinically stable (Westman et al. 2011c; McEvoy et al. 2009).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com