For example, the creation of P. pastoris strains providing a fully humanized glycosylation pattern necessitated in the first place the development of suitable genetic strategies to knock out and introduce multiple genes [ 46].
Simultaneously, the complexities of emerging risk patterns necessitate innovative approaches in DRM.
These drainage patterns necessitate extensive pelvic and para-aortic lymphadenectomy to stage the patient's disease.
The food items included in the FFQ were standardized as much as possible across ISCOLE sites; however, regional variation in food consumption patterns necessitated some cultural and regional adaptations of some of the items and examples provided.
From a biophysical point of view, regular tonic activity seems to rely mainly on SNc dopaminergic neuron intrinsic conductances while both irregular and bursting patterns necessitate the release of various neurotransmitters (glutamate, acetylcholine) by SNc synaptic inputs (Kitai et al., 1999; Grace et al., 2007).
We identified a rare case of gastric carcinosarcoma that showed a specific progression pattern, which necessitates further study of gastric carcinosarcoma.
No matter what the dynamo origin, the crustal magnetization pattern apparently necessitates contemporaneous tectonism, which the geological evidence elsewhere supports (Anguita et al. 2006).
Importantly, the temporal dynamics of biological system signals span a large dynamic range (seconds to days) with variable patterns that necessitates the need to develop devices that can reliably generate complex chemical signals precisely and repeatedly.
The presence of novel laminae in the cervical vertebrae [38], [55] and the attendant alteration of the pattern of fossae necessitate further discussion, however.
Additionally, there are few cases were schwannomas demonstrate an infiltrative pattern and tumor excision necessitates some fascicle resection.
