It is important to note that these modified individuals are, as far as we can tell, anatomically and behaviorally normal (except for the wing color-patterns), and the color-pattern modifications are thus essentially different from nonfunctional deformation or teratology caused by, for example, environmental pollutants.
On the other hand, the color-pattern modifications were indeed quite similar, if not identical, to the cold-shock-induced modifications previously reported in lycaenid butterflies [ 13, 14].
Pattern modifications have been linked to PPP regulation19.
Abnormal patterns of histone modifications are common findings in malignant cells.
How defined patterns of chromatin modifications are copied to both replicated DNA strands is presently not fully understood.
Both methylation patterns and histone modifications are involved in the epigenetic variations of this mutation [ 118, 119].
Changes in the patterns of these modifications are associated with chromatin remodelling and can result in changes in gene expression through increasingly understood mechanisms (Lachner et al, 2003).
These modifications can control gene expression and the pattern of modifications is altered in many cancers (211, 212).
It is therefore often necessary to use eukaryotic expression systems to produce correctly processed proteins, but even then the pattern of modifications is usually different from the natural situation.
This is reflected by HR and HR (ECG) appearing co-clustered, while the patterns of PR intervals modifications are slightly more distinct (correlation with HR: r = −0.67, p = 7×10−5).
Patterns of several histone modifications are cell type-specific and are stable in mitotic chromosomes [ 108].
