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To assess their general activity pattern, mice were monitored in their homecages in side-view using small CCD cameras and the ANY-maze software.
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For the single case identified in a V136 R154 Q171 homozygous sheep (O104), three of the five mice analyzed showed a predominant ∼18 kDa pattern in the brain, one a predominant ∼19 kDa PrPres pattern (mouse n°5 in Figure S2) whereas the fifth exhibited a mixed pattern [15], [17].
Whereas control GFP+ cells are interspersed with many non-labelled neighbours in a salt-and-pepper pattern, mouse Hoxb4+ cells in the midbrain and hindbrain tend to form coherent groups (Fig. 4A-D; data not shown).
This was in agreement with expression pattern in normal mouse retina and in Nrl-/ retinas compared to wild type [ 53].
Consistent with their expression patterns, mouse TLF and TBP2 variants have been shown to be involved in the development of the germ lines [9] [11].
Irf6 (GeneID: 54139), a gene expressed in facial ectoderm and critical for patterning mouse orofacial development as well as mutated in human CL/P [52], [53], [54], was also present in this category.
The colonic cytokine expression pattern of mice fed with Nissle ∆clbA was also similar to that seen in PBS-treated mice (Fig. 4E).
Interestingly, different in vivo delivery strategies affected the resulting immunity and immunodominance pattern in mice.
A parallel progression of the urinary metabolic pattern of mice treated with the 2 maize protein extracts is shown on the 2nd and 3rd discriminant axes.
Analysis of the altered mutation pattern in mice deficient in MSH2, a mismatch repair (MMR) protein, led to the proposal that SHM is a two step process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com